Double Pulse Encoding

A biological tissue's structure is the most important determinant of its function. Alterations in the function of an organ, due to pathological perturbations, or processes such as development and aging, usually stem from changes that occur at microscopic level. Consequently, an investigative tool that provides information about the underlying microscopic and organizational structure has great utility in many areas of biological science. However, most techniques that provide detailed microstructural information are invasive, and as such, they cannot be used in routine clinical practice. MRI stands out as one of the few noninvasive methods that provide spatially dependent signal within a clinically acceptable timeframe. This capability and the sensitivity of MR signal to disease-related changes have turned MRI into an indispensable clinical tool.